Table 4 Subgroup analysis.

From: Hemoglobin glycation index and mortality risk in metabolic dysfunction-associated steatotic liver disease patients: a novel U-shaped association

Characteristics

All-cause mortality

P interaction

Cardiovascular mortality

P interaction

Lower HGI

Higher HGI

P value

Lower HGI

Higher HGI

P value

HR (95% CI)

HR (95% CI)

Age

   

< 0.001

   

< 0.001

 < 60

1(Ref)

1.44 (1.12, 1.85)

0.004

 

1(Ref)

1.69 (1.07, 2.68)

0.024

 

 ≥ 60

1(Ref)

1.21 (1.01, 1.45)

0.038

 

1(Ref)

1.08 (0.76, 1.52)

0.679

 

Sex

   

0.220

   

0.223

 Male

1(Ref)

1.45 (1.19, 1.75)

< 0.001

 

1(Ref)

1.26 (0.87, 1.83)

0.222

 

 Female

1(Ref)

1.11 (0.88, 1.40)

0.373

 

1(Ref)

1.24 (0.83, 1.85)

0.298

 

Race

   

0.055

   

0.711

 Non-Hispanic White

1(Ref)

1.23 (0.87, 1.74)

0.246

 

1(Ref)

1.00 (0.49, 2.02)

0.999

 

 Non-Hispanic Black

1(Ref)

3.82 (2.05, 7.14)

< 0.001

 

1(Ref)

3.07 (0.97, 9.67)

0.056

 

 Mexican American

1(Ref)

1.27 (1.02, 1.58)

0.036

 

1(Ref)

1.13 (0.74, 1.72)

0.575

 

 Others

1(Ref)

1.19 (0.91, 1.57)

0.199

 

1(Ref)

1.33 (0.83, 2.12)

0.233

 

PIR

   

0.232

   

0.906

 < Median

1(Ref)

1.25 (1.03, 1.52)

0.021

 

1(Ref)

1.21 (0.86, 1.71)

0.275

 

 ≥ Median

1(Ref)

1.44 (1.14, 1.81)

0.002

 

1(Ref)

1.49 (0.96, 2.32)

0.076

 

CVD

   

0.292

   

0.733

 Yes

1(Ref)

1.18 (0.97, 1.44)

0.092

 

1(Ref)

1.23 (0.85, 1.78)

0.267

 

 No

1(Ref)

1.42 (1.13, 1.79)

0.003

 

1(Ref)

1.20 (0.81, 1.80)

0.363

 

Hypertension

   

0.889

   

0.637

 Yes

1(Ref)

1.20 (0.91, 1.57)

0.192

 

1(Ref)

1.39 (0.84, 2.31)

0.205

 

 No

1(Ref)

1.31 (1.1, 1.57)

0.002

 

1(Ref)

1.23 (0.89, 1.69)

0.212