Table 3 Univariable analysis of variables associated with each transition.
Variable | Transition 1 (Enrollment to CVD) | Transition 2 (Enrollment to ESKD) | Transition 3 (CVD to death) | Transition 4 (ESKD to death) | Transition 5 (Enrollment to death) | |||||
---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
Age | 1.07 (1.05, 1.09) | < 0.001 | 1.02 (1.01, 1.02) | < 0.001 | 1.120 (1.02, 1.18) | 0.017 | 1.12 (1.08, 1.16) | < 0.001 | 1.06 (1.04, 1.09) | < 0.001 |
Male (Reference: female) | 1.71 (1.17, 2.50) | 0.006 | 1.15 (0.94, 1.41) | 0.183 | 1.04 (0.34, 3.21) | 0.951 | 1.56 (0.85, 2.88) | 0.152 | 2.18 (1.14, 4.16) | 0.019 |
BMI | 1.00 (0.95, 1.05) | 0.960 | 1.01 (0.98, 1.04) | 0.416 | 0.92 (0.78, 1.08) | 0.312 | 0.99 (0.91, 1.07) | 0.726 | 0.98 (0.9, 1.07) | 0.646 |
SBP | 1.01 (1.00, 1.02) | 0.134 | 1.02 (1.01, 1.03) | < 0.001 | 1.00 (0.98, 1.02) | 0.830 | 0.99 (0.97, 1.01) | 0.172 | 1.03 (1.01, 1.04) | 0.003 |
eGFRcreatinine (per 10 ml/min/1.73m2 increment) | 0.99 (0.98, 0.99) | < 0.001 | 0.92 (0.91, 0.93) | < 0.001 | 0.98 (0.96, 1.01) | 0.246 | 0.98 (0.96, 1.01) | 0.246 | 0.98 (0.97, 0.99) | 0.001 |
log(FGF-23 + 1) | 1.07 (0.95, 1.20) | 0.253 | 1.42 (1.31, 1.53) | < 0.001 | 0.94 (0.70, 1.27) | 0.693 | 0.93 (0.77, 1.13) | 0.464 | 1.25 (1.02, 1.52) | 0.032 |
log(CRP) | 1.13 (1.00, 1.28) | 0.044 | 1.09 (1.01, 1.17) | 0.022 | 0.92 (0.65, 1.31) | 0.653 | 1.24 (1.02, 1.50) | 0.028 | 1.22 (1.01, 1.48) | 0.040 |
Spot protein-to-creatinine ratio | 1.15 (1.06, 1.25) | < 0.001 | 1.41 (1.36, 1.46) | < 0.001 | 1.06 (0.87, 1.30) | 0.567 | 0.88 (0.77, 1.00) | 0.057 | 1.28 (1.15, 1.43) | < 0.001 |
Current or former smoker (Reference: never) | 1.58 (1.12, 2.24) | 0.010 | 1.27 (1.04, 1.54) | 0.020 | 1.03 (0.40, 2.67) | 0.951 | 1.24 (0.72, 2.14) | 0.444 | 1.97 (1.11, 3.49) | 0.020 |
Cardiovascular disease history | 4.56 (3.04, 6.84) | < 0.001 | 1.84 (1.33, 2.54) | < 0.001 | 2.69 (1.37, 5.26) | 0.004 | 2.69 (1.37, 5.26) | 0.004 | 4.33 (2.21, 8.49) | < 0.001 |
CKD subtype (Reference: GN) | ||||||||||
Diabetes mellitus | 4.71 (2.97, 7.49) | < 0.001 | 3.53 (2.78, 4.48) | < 0.001 | 1.97 (0.61, 6.31) | 0.257 | 1.47 (0.74, 2.92) | 0.274 | 7.79 (3.10, 19.6) | < 0.001 |
Hypertension | 2.37 (1.41, 3.97) | 0.001 | 1.02 (0.74, 1.39) | 0.912 | 1.02 (0.23, 4.59) | 0.977 | 1.18 (0.47, 3.01) | 0.725 | 4.83 (1.85, 12.56) | 0.001 |
Polycystic kidney disease | 1.20 (0.66, 2.21) | 0.551 | 0.85 (0.62, 1.18) | 0.329 | - ** | - ** | 1.40 (0.55, 3.59) | 0.479 | 3.50 (1.29, 9.47) | 0.014 |