Fig. 4
From: Ancient DNA HLA typing reveals significant shifts in frequency in Europe since the Neolithic
Change in frequency observed between different prehistoric populations (N = HG: 48, NF: 89, BA: 17) and present day Europeans for HLA Class I alleles that presented shifts outside the 95 CI of a distribution of frequency changes from a panel of genome-wide SNPs. Panel A describes the trajectory as derived from frequencies obtained from typing at the original ≥ 2x read depth. Panel B describes the trajectory as derived from frequencies obtained from typing downsampled data at 2x read depth. Present-day frequencies are represented by the estimates from 99 CEU individuals, 91 GBR individuals, and the average of four European populations reported in the AlleleFrequencies Database (N = 20,980).
