Table 2 Immunologically relevant SNPs that exhibit changes in frequency outside the 95 CI of a distribution of frequency changes from a panel of genome-wide SNPs, across different prehistoric and present day populations.
From: Ancient DNA HLA typing reveals significant shifts in frequency in Europe since the Neolithic
SNP | Direction | Magnitude (%) | Gene | Group |
|---|---|---|---|---|
rs2227564 | Decrease | −0.21 | PLAU | Intracellular Modulators |
rs3750920 | Increase | 0.19 | TOLLIP | Intracellular Modulators |
rs11230563 | Increase | 0.29 | CD6 | Intracellular Modulators |
rs11235559 | Increase | 0.37 | PDE2A | HLA/infectious Disease |
rs3184504 | Increase | 0.43 | SH2B3 | Other |
rs653178 | Decrease | −0.45 | ATXN2 | Autoinflammatory Disorders |
rs11066188 | Increase | 0.35 | HECTD4 | Autoinflammatory Disorders |
rs10774679 | Decrease | −0.36 | OAS3 | Autoinflammatory Disorders |
rs1156361 | Decrease | −0.48 | OAS3 | HLA/infectious Disease |
rs1873613 | Increase | 0.26 | LRRK2 | Intracellular Modulators |
rs6538678 | Increase | 0.34 | CCDC38 | Systemic Lupus Erythematosus |
rs11150610 | Increase | 0.28 | ITGAM | Systemic Lupus Erythematosus |
rs11574637 | Decrease | −0.26 | ITGAM | Systemic Lupus Erythematosus |
rs2779249 | Decrease | −0.27 | NOS2A | Intracellular Modulators |
rs492602 | Increase | 0.47 | FUT2 | Autoinflammatory Disorders |
rs1429411 | Decrease | −0.42 | ANKRD44 | Systemic Lupus Erythematosus |
rs2305619 | Decrease | −0.23 | PTX3 | Intracellular Modulators |
rs708567 | Decrease | −0.29 | IL17RC | Systemic Lupus Erythematosus |
rs3775291 | Decrease | −0.32 | TLR3 | Pattern Recognition Receptors |
rs11096957 | Increase | 0.38 | TLR10 | Pattern Recognition Receptors |
rs4833095 | Decrease | −0.24 | TLR1 | Pattern Recognition Receptors |
rs5743810 | Decrease | −0.52 | TLR6 | Pattern Recognition Receptors |
rs2188962 | Increase | 0.40 | IRF1-AS1 | Autoinflammatory Disorders |
rs2549794 | Decrease | −0.25 | ERAP1 | Autoinflammatory Disorders |
rs6920220 | Decrease | −0.32 | – | Systemic Lupus Erythematosus |
rs9468413 | Increase | 0.21 | – | Other |
rs805297 | Decrease | −0.23 | APOM | Autoinflammatory Disorders |
rs9271366 | Decrease | −0.19 | – | HLA/infectious Disease |
rs2647012 | Decrease | −0.30 | – | Systemic Lupus Erythematosus |
rs2856718 | Decrease | −0.25 | – | HLA/infectious Disease |
rs7756516 | Decrease | −0.52 | HLA-DQB2 | HLA/infectious Disease |
rs7453920 | Decrease | −0.36 | HLA-DQB2 | HLA/infectious Disease |
rs2051549 | Decrease | −0.38 | HLA-DQB2 | Systemic Lupus Erythematosus |
rs13277113 | Decrease | −0.38 | BLK | Systemic Lupus Erythematosus |
rs2618476 | Decrease | −0.33 | BLK | Systemic Lupus Erythematosus |
rs1478897 | Decrease | −0.37 | – | Systemic Lupus Erythematosus |
rs4077515 | Decrease | −0.28 | CARD9 | Intracellular Modulators |
