Fig. 2

Effects of different doses of curcumin on spontaneous activity of mice. A–D. Open field test. Each group mice showed no significant difference in spontaneous activity. 300 mg curcumin group showed a decreasing spontaneous activity trend compared with other groups. (A) Distance in edge zone of mice in the OFT. (B) Total distance of mice in the OFT. (C) Edge/total distance of mice in the OFT. (D) Track map of mice in the OFT. All data are expressed as mean ± SEM, n = 6, *p < 0.05, **p < 0.01 versus Con group, #p < 0.05, ##p < 0.01 versus H14d group.