Table 2 Association of LE8 with all-cause mortality in the MASLD population, NHANES 2005–2018.

From: Association of life’s essential 8 with all-cause and cause-specific mortality in metabolic dysfunction-associated steatotic liver disease

All-cause

Crude model

HR (95%CI)

P-value

Model 1

HR (95%CI)

P-value

Model 2

HR (95%CI)

P-value

LE8

0.963(0.956,0.971)

< 0.0001

0.965(0.957,0.973)

< 0.0001

0.973(0.965,0.981)

< 0.0001

LE8

 Low CVH

1 (reference)

/

1 (reference)

/

1 (reference)

/

 Moderate CVH

0.419(0.352,0.500)

< 0.0001

0.475(0.399,0.567)

< 0.0001

0.564(0.469,0.678)

< 0.0001

 High CVH

0.189(0.096,0.374)

< 0.0001

0.246(0.126,0.478)

< 0.0001

0.330(0.169,0.646)

0.001

 P for trend

 

< 0.0001

 

< 0.0001

 

< 0.0001

 Health behaviors

0.984(0.979,0.989)

< 0.0001

0.978(0.973,0.982)

< 0.0001

0.982(0.978,0.987)

< 0.0001

Health behaviors

 Low CVH

1 (reference)

/

1 (reference)

/

1 (reference)

/

 Moderate CVH

0.601(0.511,0.706)

< 0.0001

0.508(0.438,0.589)

< 0.0001

0.599(0.509,0.704)

< 0.0001

 High CVH

0.421(0.318,0.558)

< 0.0001

0.332(0.262,0.420)

< 0.0001

0.427(0.333,0.548)

< 0.0001

 P for trend

 

< 0.0001

 

< 0.0001

 

< 0.0001

Health factors

0.973(0.967,0.979)

< 0.0001

0.987(0.981,0.994)

< 0.001

0.991(0.984,0.997)

0.004

Health factors

 Low CVH

1 (reference)

/

1 (reference)

/

1 (reference)

/

 Moderate CVH

0.489(0.413,0.578)

< 0.0001

0.724(0.606,0.865)

< 0.001

0.780(0.658,0.924)

0.004

 High CVH

0.443(0.290,0.675)

< 0.001

0.996(0.676,1.467)

0.983

1.095(0.736,1.629)

0.655

 P for trend

 

< 0.0001

 

0.005

 

0.037

  1. The crude model did not adjust for any covariates, model 1 adjusted for age, sex, and race/ethnicity, and model 2 was a fully adjusted model that additionally adjusted for education level, PIR(Polyisocyanurate Foam), marital status, and CVD history based on model 1. Bold indicates statistical significance.