Table 3 Association of LE8 with CVD mortality in the MASLD population, NHANES 2005–2018.

From: Association of life’s essential 8 with all-cause and cause-specific mortality in metabolic dysfunction-associated steatotic liver disease

CVD

Crude model

HR (95%CI)

P-value

Model 1

HR (95%CI)

P-value

Model 2

HR (95%CI)

P-value

LE8

0.962(0.949,0.975)

< 0.0001

0.964(0.949,0.979)

< 0.0001

0.973(0.958,0.989)

< 0.001

LE8

 Low CVH

1 (reference)

/

1 (reference)

/

1 (reference)

/

 Moderate CVH

0.394(0.286,0.543)

< 0.0001

0.454(0.326,0.632)

< 0.0001

0.554(0.397,0.773)

< 0.001

 High CVH

0.178(0.057,0.558)

0.003

0.243(0.078,0.756)

0.015

0.354(0.117,1.000)

0.047

 P for trend

 

< 0.0001

 

< 0.0001

 

< 0.001

 Health behaviors

0.989(0.981,0.998)

0.014

0.983(0.974,0.992)

< 0.001

0.990(0.980,0.999)

0.031

Health behaviors

 Low CVH

1 (reference)

/

1 (reference)

/

1 (reference)

/

 Moderate CVH

0.679(0.500,0.922)

0.013

0.564(0.423,0.753)

< 0.0001

0.697(0.520,0.935)

0.016

 High CVH

0.606(0.393,0.935)

0.024

0.476(0.307,0.740)

< 0.001

0.674(0.431,1.055)

0.084

 P for trend

 

0.023

 

0.001

 

0.073

 Health factors

0.963(0.954,0.972)

< 0.0001

0.976(0.964,0.987)

< 0.0001

0.980(0.968,0.991)

< 0.001

Health factors

 Low CVH

1 (reference)

/

1 (reference)

/

1 (reference)

/

 Moderate CVH

0.424(0.319,0.565)

< 0.0001

0.646(0.472,0.885)

0.006

0.703(0.515,0.961)

0.027

 High CVH

0.146(0.066,0.323)

< 0.0001

0.347(0.152,0.791)

0.012

0.393(0.178,0.866)

0.02

 P for trend

 

< 0.0001

 

0.001

 

0.008

  1. The crude model did not adjust for any covariates, model 1 adjusted for age, sex, and race/ethnicity, and model 2 was a fully adjusted model that additionally adjusted for education level, PIR, marital status, and CVD history based on model 1. Bold indicates statistical significance.