Table 4 Association of LE8 with cancer-related mortality in the MASLD population, NHANES 2005–2018.

From: Association of life’s essential 8 with all-cause and cause-specific mortality in metabolic dysfunction-associated steatotic liver disease

Cancer

Crude model

HR (95%CI)

P-value

Model 1

HR (95%CI)

P-value

Model 2

HR (95%CI)

P-value

LE8

0.978(0.967,0.989)

< 0.0001

0.981(0.969,0.993)

0.002

0.984(0.971,0.997)

0.014

LE8

 Low CVH

1 (reference)

/

1 (reference)

/

1 (reference)

/

 Moderate CVH

0.650(0.447,0.943)

0.023

0.726(0.497,1.060)

0.097

0.780(0.529,1.151)

0.211

 High CVH

0.059(0.016,0.221)

< 0.0001

0.074(0.020,0.280)

< 0.001

0.083(0.021,0.326)

< 0.001

 P for trend

 

< 0.001

 

0.003

 

0.016

 Health behaviors

0.987(0.979,0.995)

< 0.001

0.981(0.973,0.989)

< 0.0001

0.982(0.974,0.991)

< 0.0001

Health behaviors

 Low CVH

1 (reference)

/

1 (reference)

/

1 (reference)

/

 Moderate CVH

0.832(0.603,1.147)

0.261

0.700(0.504,0.972)

0.033

0.748(0.534,1.049)

0.093

 High CVH

0.529(0.323,0.867)

0.011

0.413(0.258,0.662)

< 0.001

0.453(0.275,0.748)

0.002

 P for trend

 

0.008

 

< 0.001

 

0.001

 Health factors

0.989(0.978,1.001)

0.078

1.006(0.993,1.019)

0.375

1.007(0.994,1.020)

0.282

Health factors

 Low CVH

1 (reference)

/

1 (reference)

/

1 (reference)

/

 Moderate CVH

0.807(0.562,1.160)

0.247

1.183(0.818,1.711)

0.372

1.228(0.853,1.769)

0.269

 High CVH

0.857(0.390,1.884)

0.701

1.888(0.867,4.111)

0.11

1.976(0.913,4.281)

0.084

 P for trend

 

0.358

 

0.155

 

0.1

  1. The crude model did not adjust for any covariates, model 1 adjusted for age, sex, and race/ethnicity, and model 2 was a fully adjusted model that additionally adjusted for education level, PIR, marital status, and CVD history based on model 1. Bold indicates statistical significance.