Correction to: Scientific Reports https://doi.org/10.1038/s41598-021-84082-3, published online 08 March 2021
The original version of this Article contained an error in Figure 2, panel C. During Figure preparation, the NT control well in the Palbociclib condition was mistakenly duplicated from the Dinaciclib condition. The original Fig. 2 and accompanying legend appear below.
Dinaciclib shows stronger inhibitory responses than palbociclib in medulloblastoma. (A) Growth rates over 72 h of HD-MB03 cells treated with dinaciclib (top) or palbociclib (bottom) at the indicated concentrations. (B) Representative phase-contrast images of HD-MB03 cells treated with IC50 and 100xIC50 doses of dinaciclib and palbociclib for 72 h. Images were captured at 100 × total magnification. (C) Representative crystal violet staining images of long-term proliferation assay. HD-MB03 cells were treated with the indicated drugs for 9 days and then fixed and stained. On the right, crystal violet quantifications relative to the presented images. (D) Representative crystal violet staining images showing resistant HD-MB03 colonies arising after dinaciclib and palbociclib wash-out over 12 days recovery. Pre-treatments with each drug were carried out over 24 h before wash-out. (E) Percentages of cell viability inhibition of HD-MB03 medullospheres after 72 h treatment with different doses of dinaciclib or palbociclib, calculated as relative to untreated control. Statistical comparisons were performed using an unpaired, two-tailed Student t-test where **P < 0.01; ***P < 0.001. Plotted graphs show mean ± SD (n = 3).
The original Article has been corrected.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Buzzetti, M., Morlando, S., Solomos, D. et al. Author Correction: Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells. Sci Rep 15, 4384 (2025). https://doi.org/10.1038/s41598-024-83271-0
Published:
DOI: https://doi.org/10.1038/s41598-024-83271-0