Table 4 Characteristics of studies included in the meta-analysis of NOS3 rs2070744 and rs1799983 variants.

From: Association of endothelial nitric oxide synthase (NOS3) rs2070744 variant with advanced retinopathy of prematurity: a case–control study and meta-analysis

First author

Country (ethnicity)

Genotyping method

Cases/controls

Cases

Controls

Whole group MAFs

Whole group PHWE

Controls PHWE

Quality score

rs2070744 (-786 T > C)

TT

TC

CC

T

C

TT

TC

CC

T

C

   

ROP

  

This study 2023

Poland (Caucasian)

TaqMan test

180/105

72

81

27

225

135

43

43

19

129

81

0.379

0.442

0.164

9

Tekkeşin F 2022

Turkey (Caucasian)

PCR-RFLP

69/70

29

34

6

92

46

37

26

7

100

40

0.309

0.993

0.452

7

Pantelić 2016

Serbia (Caucasian)

PCR-RFLP

60/68

24

31

5

79

41

26

36

6

88

48

0.348

0.219

0.190

6

Poggi 2015

Italy (Caucasian)

TaqMan test

43/299

15

16

12

46

40

116

131

52

363

235

0.402

0.146

0.158

7

Yu 2015

China (Asian)

MassArray

118/134

72

39

7

183

53

68

51

15

187

81

0.266

0.401

0.258

9

Yanamandra 2010

USA (Caucasian)

PCR-RFLP

8/47

1

6

1

8

8

29

14

4

72

22

0.273

0.826

0.246

8

ROP requiring treatment

This study 2023

Poland (Caucasian)

TaqMan test

90/195

41

42

7

124

56

74

82

39

230

160

0.379

0.442

0.067

9

Ilguy S 2021

Turkey (Caucasian)

SnapShot

73/75

64

9

0

137

9

61

4

10

126

24

0.111

0.001

0.001

7

Rusai 2007

Hungry (Caucasian)

PCR-RFLP

135/127

47

79

9

173

97

55

60

12

170

84

0.345

0.020

0.449

9

rs1799983 (894 G > T; Glu298Asp)

GG

GT

TT

G

T

GG

GT

TT

G

T

   

ROP

  

This study 2023

Poland (Caucasian)

TaqMan test

180/104

99

66

15

264

96

54

42

8

150

58

0.271

0.442

0.966

9

Tekkeşin F 2022

Turkey (Caucasian)

PCR-RFLP

69/70

41

23

5

105

33

40

28

2

108

32

0.234

0.993

0.261

7

Poggi 2015

Italy (Caucasian)

TaqMan test

43/299

15

24

4

54

32

151

121

27

423

175

0.303

0.219

0.697

7

Yu 2015

China (Asian)

MassArray

118/134

87

28

3

202

34

89

43

2

221

47

0.161

0.146

0.205

9

Yanamandra 2010

USA (Caucasian)

PCR-RFLP

8/47

3

3

2

9

7

35

11

1

81

13

0.182

0.401

0.902

8

ROP requiring treatment

  

This study 2023

Poland (Caucasian)

TaqMan test

90/194

48

33

9

129

51

105

75

14

285

103

0.271

0.826

0.904

9

Ilguy S 2021

Turkey (Caucasian)

SnapShot

73/75

59

10

4

128

18

63

10

2

136

14

0.108

0.442

0.066

7

  1. PCR-RFLP Polymorphism chain reaction- restriction fragment length polymorphism, MAF Minor allelic frequency, HWE Hardy–Weinberg equilibrium, Studies with scores of 0–3, 4–6, 7–9 were, respectively, considered as low, moderate, and high quality.
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