Table 5 Meta-analysis results of association of NOS3 variants with ROP risk.
Variant/analysis | Genetic model | Type of model | Heterogeneity | Statistical analysis | Publi-cation bias; PEggers | |||||
|---|---|---|---|---|---|---|---|---|---|---|
I2 (%) | PH | OR | 95% CI | Pcrude | Padjusted | |||||
rs2070744 (-786 T > C) | ||||||||||
ROP | Allele contrast | C vs. T | REM | 54 | 0.05 | 1.06 | 0.79–1.43 | 0.680 | 1.000 | 0.099 |
Recessive | CC vs. TC + TT | FEM | 08 | 0.37 | 0.96 | 0.66–1.40 | 0.839 | 1.000 | 0.970 | |
Dominant | CC + TC vs. TT | FEM | 47 | 0.10 | 1.01 | 0.78–1.32 | 0.913 | 1.000 | 0.049 | |
Overdominant | TC vs. CC + TT | FEM | 42 | 0.12 | 1.06 | 0.82–1.38 | 0.650 | 1.000 | 0.132 | |
Homozygotes | CC vs. TT | FEM | 25 | 0.25 | 0.97 | 0.65–1.47 | 0.901 | 1.000 | 0.466 | |
Heterozygotes | TC vs. TT | FEM | 42 | 0.13 | 1.05 | 0.79–1.38 | 0.749 | 1.000 | 0.068 | |
ROP requiring treatment | Allele contrast | C vs. T | REM | 78 | 0.01 | 0.69 | 0.39–1.23 | 0.209 | 1.000 | 0.462 |
Recessive | CC vs. TC + TT | FEM | 48 | 0.15 | 0.42 | 0.23–0.77 | 0.005 | 0.036 | 0.427 | |
Dominant | CC + TC vs. TT | REM | 56 | 0.10 | 0.92 | 0.54–1.55 | 0.745 | 1.000 | 0.659 | |
Overdominant | TC vs. CC + TT | FEM | 00 | 0.50 | 1.45 | 1.03–2.03 | 0.032 | 0.222 | 0.461 | |
Homozygotes | CC vs. TT | REM | 59 | 0.09 | 0.39 | 0.12–1.21 | 0.104 | 0.725 | 0.517 | |
Heterozygotes | TC vs. TT | FEM | 23 | 0.27 | 1.26 | 0.89–1.80 | 0.198 | 1.000 | 0.662 | |
rs1799983 (894 G > T) | ||||||||||
ROP | Allele contrast | T vs. G | REM | 60 | 0.04 | 1.17 | 0.80–1.71 | 0.417 | 1.000 | 0.107 |
Recessive | TT vs. GT + GG | FEM | 13 | 0.33 | 1.45 | 0.80–2.61 | 0.217 | 1.000 | 0.036 | |
Dominant | TT + GT vs. GG | REM | 57 | 0.05 | 1.11 | 0.70–1.77 | 0.647 | 1.000 | 0.126 | |
Overdominant | GT vs. TT + GG | FEM | 45 | 0.12 | 0.93 | 0.70–1.24 | 0.644 | 1.000 | 0.459 | |
Homozygotes | TT vs. GG | FEM | 20 | 0.29 | 1.65 | 0.85–2.87 | 0.153 | 1.000 | 0.044 | |
Heterozygotes | GT vs. GG | REM | 52 | 0.08 | 1.02 | 0.65–1.61 | 0.920 | 1.000 | 0.268 | |
ROP requiring treatment | Allele contrast | T vs. G | FEM | 00 | 0.60 | 1.15 | 0.81–1.63 | 0.434 | 1.000 | N/A. |
Recessive | TT vs. GT + GG | FEM | 00 | 0.69 | 1.55 | 0.71–3.39 | 0.274 | 1.000 | N/A. | |
Dominant | TT + GT vs. GG | FEM | 00 | 0.71 | 1.08 | 0.70–1.67 | 0.715 | 1.000 | N/A. | |
Overdominant | GT vs. TT + GG | FEM | 00 | 0.83 | 0.94 | 0.60–1.48 | 0.802 | 1.000 | N/A. | |
Homozygotes | TT vs. GG | FEM | 00 | 0.68 | 1.54 | 0.69–3.43 | 0.293 | 1.000 | N/A. | |
Heterozygotes | GT vs. GG | FEM | 00 | 0.85 | 0.99 | 0.62 – 1.57 | 0.956 | 1.000 | N/A. | |
