Fig. 1
From: The IL-10/STAT3 Axis Nasopharyngeal Carcinoma Cancer stem cell and radio resistance
IL-10 gene is linked to NPC radio resistance and can potentially predict NPC radio resistance. (A, B) The amounts of IL-10 mRNA (A) and IL-10 secretion into the supernatant were analyzed via RT-qPCR and ELISA in NPC cells, respectively. The enzyme GAPDH could be applied as a reference standard. (C) Individuals with radioresistant NPC (n = 25) had an elevated serum IL-10 level compared to those with radiosensitive NPC (n = 30). (D) Predictive value of serum IL-10 in differentiating radioresistant NPC from radiosensitive NPC shown by ROC curves. (E) Kaplan–Meier analysis of the RFS and OS between high and low serum IL-10 cohorts. (F) Uni-and multivariate analyses in RFS and OS. (G) Up panel: Percentage of HIF1α-negative, HIF1α-moderate, and HIF1α-high cases in High serum IL-10 or Low serum IL-10 group. Down panel: The representative images of HIF1α-negative, HIF1α-moderate, and HIF1α-high cases from NPC tissues. scale bars: 2000µM. For(A-C) Student’s t-test, (D)ROC test, (E) the log-rank test, (F) Single factor and multiple factor logistic regression. Error bars show mean ± SD derived from n = 3 independent experiments, *p < 0.05.
