Fig. 4
From: Decoding the general role of tRNA queuosine modification in eukaryotes
Graphical scheme of the processes that are predicted to be dysregulated by Q-tRNAs depletion in cancer cells. Several studies reported that tRNA Q-modification is impaired in different types of tumours. Data presented in this work and in previous studies indicate that Q-tRNAs may control diverse processes critical in carcinogenesis, such as, ubiquitination, ER stress and UPR, cell adhesion, proliferation, splicing, PI metabolism or DNA repair, and we suggest that Akt activation and p53 expression could be dysregulated by Q depletion in human cells.
