Table 2 Univariate and multivariate Cox regression analyses of PFS in the overall population.

From: Presence of liver metastasis correlated with high tumor abundance and indicated adverse prognostic feature in EGFR mutation non-small-cell lung cancer patients

Variablesa

Univariate

Multivariate

HR (95% CI)

P-value

HR (95% CI)

P-value

Age (< 60/≥60)

1.16 (0.67–1.98)

0.60

  

Gender (male/female)

1.03 (0.60–1.75)

0.92

  

ECOG PS (≥ 2/0–1)

1.71 (0.89–3.29)

0.11

  

Smoking (ever/never)

0.98 (0.55–1.76)

0.95

  

Histology (non-ADC/ADC)

0.68 (0.21–2.17)

0.52

  

Number of metastatic sites (≥ 3/<3)

2.15 (1.30–3.58)

0.003*

1.73 (0.92–3.25)

0.09

Brain metastasis (yes/no)

1.31 (0.75–2.29)

0.35

0.88 (0.49–1.61)

0.69

Liver metastasis (yes/no)

2.79 (1.61–4.83)

< 0.001*

2.41 (1.27–4.60)

0.007*

EGFR subtype (uncommon/common)

4.09 (1.69–9.86)

0.002*

7.71 (2.97–19.99)

< 0.001*

Common EGFR subtype (Del19/L858R)

1.13 (0.64–1.98)

0.68

  

Line of TKI (first/later)

0.80 (0.25–2.55)

0.70

  

Generation of TKI (first/second-third)

4.57 (0.63–33.13)

0.13

  

Detectable ctEGFR (yes/no)

1.74 (1.05–2.89)

0.03*

1.57 (0.93–2.64)

0.09

  1. aCategory after the slash (/) was set as a reference category. ADC: adenocarcinoma, ctDNA: circulating tumor DNA, Del19: exon 19 deletions, ECOG PS: Eastern Cooperative Oncology Group performance status, EGFR: epidermal growth factor receptor, TKI: tyrosine kinase inhibitor.
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