Table 3 Univariate and multivariate Cox regression analyses of OS in the overall population.

From: Presence of liver metastasis correlated with high tumor abundance and indicated adverse prognostic feature in EGFR mutation non-small-cell lung cancer patients

Variablesa

Univariate

Multivariate

HR (95% CI)

P-value

HR (95% CI)

P-value

Age (< 60/≥60)

0.82 (0.40–1.68)

0.58

  

Gender (male/female)

1.09 (0.56–2.13)

0.81

  

ECOG PS (≥ 2/0–1)

2.34 (1.11–4.95)

0.03*

2.21 (1.03–4.73)

0.04*

Smoking (ever/never)

0.76 (0.35–1.66)

0.50

  

Histology (non-ADC/ADC)

1.28 (0.39–4.15)

0.69

  

Number of metastatic sites (≥ 3/<3)

1.92 (1.01–3.67)

0.05*

1.01 (0.47–2.18)

0.97

Brain metastasis (yes/no)

1.26 (0.62–2.53)

0.52

  

Liver metastasis (yes/no)

3.34 (1.70–6.53)

< 0.001*

2.96 (1.35–6.51)

0.007*

EGFR subtype (uncommon/common)

2.34 (0.83–6.62)

0.11

  

Common EGFR subtype (Del19/L858R)

0.78 (0.39–1.56)

0.49

  

Line of TKI (first/later)

2.16 (0.30–15.77)

0.45

  

Generation of TKI (first/second)

2.24 (0.30–16.50)

0.43

  

Detectable ctEGFR (yes/no)

2.38 (1.22–4.64)

0.01*

1.99 (1.00–3.98)

0.05*

  1. aCategory after the slash (/) was set as a reference category. ADC: adenocarcinoma, ctDNA: circulating tumor DNA, Del19: exon 19 deletions, ECOG PS: Eastern Cooperative Oncology Group performance status, EGFR: epidermal growth factor receptor, TKI: tyrosine kinase inhibitor.
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