Table 4 Effect of index case CAC status on Mtb infection in household contacts.

From: Association of Mycobacterium tuberculosis aerosolization and HIV coinfection in the index case with T cell responses in household contacts

Mtb infection endpoint

CAC- Exposure

CAC + Exposure

p-value*

OR (95% CI)*

aOR (95% CI)*

Na

(n, %)b

Nc

(n, %)d

Any ESAT6/CFP10 response

 QFT-Plus (IFN-γ)

195

107 (54.9%)

25

22 (88.0%)

0.013

11.50 (1.68, 78.7)

29.35 (1.83, 471.40)†

 IL-2

184

99 (53.8%)

26

22 (84.6%)

0.022

6.98 (1.33, 36.75)

12.64 (1.87, 85.40)††

 TNF

134

49 (36.6%)

17

6 (35.3%)

0.944

0.96 (0.30, 3.09)

–

Composite measure**

201

133 (66.2%)

26

23 (88.5%)

0.041

5.37 (1.07, 27.0)

11.2 (1.55, 80.21)††††

Any 2 ESAT6/CFP10 response including QFT-Plus (IFN-γ)

 QFT-Plus (IFN-γ) or IL-2

201

116 (57.7%)

26

22 (84.6%)

0.038

5.70 (1.10, 29.56)

14.91 (1.63, 136.28)†††

 QFT-Plus (IFN-γ) or TNF

200

126 (63.0%)

26

23 (88.5%)

0.025

6.48 (1.27, 33.11)

13.6 (1.89, 98.63)††††

  1. CAC, Cough Aerosol Culture; N includes only HHC with the various cytokine measures; aTotal HHC exposed to index with Negative CAC; bNumber and percentage of HHC with a positive ESAT6/CFP10 response as specified in the respective row among those exposed to CAC- index ; cTotal HHC exposed to index with Positive CAC; bNumber and percentage of HHC with a positive ESAT6/CFP10 response as specified in the respective row among those exposed to CAC + index; *Mixed-effects logistic regression; **(QFT-Plus IFN-γ + IL-2 + TNF+); †adjusted for HHC age, index HIV status, index cavitary disease, index CRP; ††adjusted for index cavitary disease; †††adjusted for HHC age and index cavitary disease; ††††adjusted for index cavitary disease
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