Fig. 2 | Scientific Reports

Fig. 2

From: ALKBH5 acts a tumor-suppressive biomarker and is associated with immunotherapy response in hepatocellular carcinoma

Fig. 2

ALKBH5 inhibits proliferation and migration and promotes apoptosis of HCC cells. (A) Western blot analysis showing ALKBH5 levels in HepG2-cells with stable ALKBH5 overexpression and Hep3B-cells with stable ALKBH5 knockdown. (B) CCK-8 assays showed that ALKBH5 overexpression inhibited cell proliferation and ALKBH5 knockdown promoted cell proliferation. (C, D) Colony formation assays of HCC cell lines with ALKBH5 overexpression or knockdown. (E) Images of subcutaneous tumor in Hep3B cells xenograft implantation model. (F-G) Tumor volume and weight of subcutaneous tumor (n = 6). (*P < 0.05, **P < 0.01, ***P < 0.001).

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