Fig. 3 | Scientific Reports

Fig. 3

From: ALKBH5 acts a tumor-suppressive biomarker and is associated with immunotherapy response in hepatocellular carcinoma

Fig. 3

(A, B) Cell cycle assays showed that ALKBH5 overexpression induced cell cycle arrest at the G1/S phase and that ALKBH5 knockdown accelerated cell cycle progression at the G1/S phase. (C, D) Cell migration assays showed that ALKBH5 overexpression abolished the cell migration capabilities and ALKBH5 knockdown increased the cell migration capabilities. (E, F) Overexpression of ALKBH5 promoted cell apoptosis, and knockdown of ALKBH5 decreased cell apoptosis in cell apoptosis assays. (G-I)Downregulation of ALKBH5 promoted the metastasis of Hep3B cells in vivo, and the number of liver metastasis nodules and liver weights in the mice was determined (n = 6). (*P < 0.05, **P < 0.01).

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