Fig. 5
Identification of the MRGs and HCC molecular subtypes. (A) The overall design of the whole study. (B) Upregulated/downregulated (blue circle) and hypermethylated (red circle) transcripts were combined using a Venn diagram. 39 transcripts containing in the overlap were identified as MRGs. (C) Expression of MRGs in HCC tissues and normal tissues based on the TCGA database. (D) Batch survival analysis of MRGs and 6 prognosis-related MRGs (P value < 0.01) were defined as the key MRGs. (E) Consensus clustering of HCC patients in the TCGA cohort according to the expression of key MRGs. (F) PCA of HCC subtypes. (G) The expression of 6 key MRGs in different HCC subtypes. (H, I) Kaplan–Meier curves for OS and PFS of different HCC subtypes. (*P < 0.05, **P < 0.01, ***P < 0.001).
