Table 4 Detailed information of the top potential targeted drugs predicted by the DGIdb database.
Gene | Drug | Regulatory approval | Indication | Interaction score |
|---|---|---|---|---|
CYP1B1 | 2'H,4H-[2,8'-BICHROMEN]-4-ONE | Not approved | 4.212861 | |
CYP1B1 | CHEMBL:CHEMBL2347759 | Not approved | 4.212861 | |
CYP1B1 | PINOCEMBRIN | Not approved | 2.10643 | |
CYP1B1 | ZYC300 | Not approved | Antineoplastic agent | 2.10643 |
CYP1B1 | ISOPROPYL ALCOHOL | Approved | 1.404287 | |
CYP1B1 | BETA-NAPHTHOFLAVONE | Not approved | 1.404287 | |
CYP1B1 | FORMESTANE | Not approved | 1.053215 | |
CYP1B1 | FADROZOLE | Not approved | 0.842572 | |
CYP1B1 | AMINOGLUTETHIMIDE | Approved | Antineoplastic agents | 0.601837 |
CYP1B1 | MEDROXYPROGESTERONE | Approved | 0.601837 | |
CYP1B1 | ALPHA-NAPHTHOFLAVONE | Not approved | 0.601837 | |
CYP1B1 | AMODIAQUINE | Not approved | 0.526608 | |
CYP1B1 | TOREMIFENE | Approved | SERM,antineoplastic agent | 0.324066 |
CYP1B1 | NARINGENIN | Not approved | 0.300919 | |
CYP1B1 | ANASTROZOLE | Approved | antineoplastic agent | 0.300919 |
CYP1B1 | CHRYSIN | Approved | 0.300919 | |
CYP1B1 | ADJUVANT | Not approved | 0.280857 | |
CYP1B1 | ACACETIN | Not approved | 0.280857 | |
CYP1B1 | EXEMESTANE | Approved | Antineoplastic agent | 0.263304 |
CYP1B1 | SPIRONOLACTONE | Approved | Antihypertensive agent | 0.247815 |
CYP1B1 | LETROZOLE | Approved | Antineoplastic agent | 0.22173 |
CYP1B1 | EPIRUBICIN | Approved | Antineoplastic agents | 0.203848 |
CYP1B1 | RIFAMPIN | Approved | 0.183168 | |
CYP1B1 | CYCLOPHOSPHAMIDE ANHYDROUS | Approved | 0.087768 | |
CYP1B1 | RISPERIDONE | Approved | Antipsychotic agents,antipsychotic agent | 0.041303 |
CYP1B1 | FLUOROURACIL | Approved | 0.039744 | |
CYP1B1 | DOXORUBICIN HYDROCHLORIDE | Approved | antineoplastic agent | 0.014628 |
