Table 3 In silico prediction of human CYPs substrate (S) or inhibition (I) by thiohydantoins THD1, THD3, and THD5.

From: In vitro assays identified thiohydantoins with anti-trypanosomatid activity and molecular modelling studies indicated possible selective CYP51 inhibition

CYP

CYP1A2

CYP2C19

CYP2C9

CYP2D6

CYP3A4

I

S

I

S

I

S

I

S

I

S

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No

No

No

No

No

No

No

No

No

No

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No

No

No

No

No

No

No

No

No

No

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No

No

No

No

No

Yes

No

No

No

No

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