Table 1 The essential functions, major system components, functional modules, and supported automated cell culture processes of BECA-Auto.

From: Transition from manual to automated processes for autologous T cell therapy manufacturing using bioreactor with expandable culture area

Essential functions

System components

Functional modules

Supported processes

Cell culture

Single-use kits

BECA-S (closed)

Cell culture

Fluid transfer

Manifold Assembly

Input Manifold

Seeding

Media feed

Harvesting

Fluid manipulation

Control units

Capsule lnternal Fluid Controller (CIFC)

Seeding

Media feed

Harvesting

Automated sampling

Device for Automated Aseptic Sampling (DAAS)

Culture sampling

Expansion of culture region and positioning of vessel

Actuation Platform

Culture area expansion

Culture resuspension

Environmental control

Enclosure

Climate Control

Cell culture