Fig. 5

Proteomic analysis of dAM + TDSCs group involved in the repair of Achilles tendon rupture. (A) Proteins between control and dAM + TDSCs groups Venn diagrams. (B) Volcano plot of differentially expressed proteins between dAM + TDSCs and control. In order to show the significant difference of proteins between the comparison groups, the significantly down-regulated proteins are marked in blue (FC < 1.5 and p < 0.05), the significantly up-regulated proteins are marked in red (FC > 1.5 and p < 0.05), and the proteins with no difference are marked in gray. (C) The differentially expressed proteins in the control and dAM + TDSCs groups were compared with all the proteins in the reference species by GO function annotation, and the resulting bubble plot was obtained. (D) KEGG pathway annotation and attribution bar chart of differentially expressed proteins between control and dAM + TDSCs groups. The horizontal axis represents the number of pathway protein annotations, and the vertical axis represents the KEGG annotation name. Different colors represent the seven branches of KEGG metabolic pathways. (E) GSEA plot of Ribosome. (F) GSEA plot of Protein processing in endoplasmic reticulum. (G) GSEA plot of ECM-receptor Interaction. (H) GSEA plot of Tight junction. (I) GSEA plot of Focal adhesion. (J) GSEA plot of HIF-1 signaling pathway.