Table 1 Demographic and clinical characteristics of participants.

Age (years) (median, IQR)

65.0 (59.0, 70.0)

72.0 (68.2, 74.0)

< 0.0001

Sex (female, n (%))

75 (57%)

78 (62%)

0.27

ApoE Genotype (n, %)

ε4-allele non-carrier

106 (80%)

63 (47%)

< 0.0001

Homozigous ε4-allele carrier

2 (1.5%)

10 (7%)

Heterozigous ε4-allele carrier

24 (18%)

61 (45%)

Educational level* (n, %)

0

31 (24%)

43 (32%)

0.009

1

21 (16%)

33 (25%)

2

32 (24%)

19 (14%)

3

43 (33%)

32 (24%)

4

0 (0%)

5 (4%)

CDR (n, %)

0

25 (19%)

8 (6%)

0.001

0.5

90 (68%)

100 (75%)

1

14 (11%)

22 (16%)

2

2 (1.5%)

3 (2%)

CDR sum of boxes (scores) (median, IQR)

1.75 (1, 4)

3.5 (2, 5)

< 0.0001

MMSE (scores) (median, IQR)

27 (25, 29)

24 (20, 27)

< 0.0001

RBANS_IM (scores) (median, IQR)

81 (73, 90)

65 (53, 76)

< 0.0001

RBANS_V/C (scores) (median, IQR)

87 (72, 100)

75 (64, 85)

0.001

RBANS_A (scores) (median, IQR)

75 (56, 94)

64 (53, 82)

0.0013

RBANS_L (scores) (median, IQR)

85 (68, 94)

68 (57, 86)

< 0.0001

RBANS_DM (scores) (median, IQR)

84 (68, 98)

52 (40, 71)

< 0.0001

FAQ (scores) (median, IQR)

3 (1, 10)

7 (3, 13)

0.001

ADCS_ADL_MCI (scores) (median, IQR)

43 (32, 48)

39 (34, 45)

0.012

GDS (scores) (median, IQR)

13 (7, 18)

9 (6, 15)

0.001

CSF_Aβ42 (pg mL⁻¹) (median, IQR)

1211.0 (927, 1444.5)

635 (495, 794)

< 0.0001

CSF t-Tau (pg mL⁻¹) (median, IQR)

219 (156, 318)

685 (472, 895)

< 0.0001

CSF p-Tau181 (pg mL⁻¹) (median, IQR)

32 (26, 44)

112 (79, 149)

< 0.0001

CSF Aβ40 (pg mL⁻¹) (median, IQR)

11,359 (9095, 13,707)

12,806 (10,451, 16,772)

0.001

CSF Aβ42/Aβ40 (pg mL⁻¹) (median, IQR)

0.11 (0.10, 0.12)

0.05 (0.04, 0.06)

< 0.0001

CSF NfL (pg mL⁻¹) (median, IQR)

660 (438, 1209)

1162 (893, 1825)

< 0.0001

CSF Aβ42/t-Tau (pg mL⁻¹) (median, IQR)

0.2 (0.1, 0.3)

1.1 (0.8, 1.5)

< 0.0001