Table 4 Diagnosis indexes for the developed models, using cut-off = 0.5 (AD probability).

From: Promising clinical tools for specific Alzheimer disease diagnosis from plasma pTau217 and ApoE genotype in a cognitive disorder unit

 

Model A

Model B

Variables

Plasma p-Tau217

Plasma p-Tau217 + ApoE + age

Sensitivity (CI 95%)

0.72 (0.60–0.83)

0.85 (0.73–0.95)

Specificity (CI 95%)

0.96 (0.90–1)

0.89 (0.79–0.97)

PPV (CI 95%)

0.95 (0.88–1)

0.89 (0.80–0.97)

NPV (CI 95%)

0.77 (0.69–0.85)

0.85 (0.76–0.95)

Accuracy (CI 95%)

0.84 (0.77–1)

0.87 (0.80–0.94)

AUC (CI 95%)

0.93 (0.88–0.97)

0.94 (0.90–0.98)

  1. CI Confidence interval.
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