Table 5 Cut-offs for the developed models according to different threshold criteria.

From: Promising clinical tools for specific Alzheimer disease diagnosis from plasma pTau217 and ApoE genotype in a cognitive disorder unit

 

Threshold criteria

Low cut-off

High cut-off

TN

FN

TP

FP

Grey area (n)

Model A

95% Sens/Spec

0.37

0.49

75

4

97

4

86

95% NPV/PPV

0.36

0.49

58

3

97

4

104

90% Sens/Spec

0.40

0.44

100

11

111

13

31

Model B

95% Sens/Spec

0.41

0.57

94

6

92

6

68

95% NPV/PPV

0.38

0.58

78

4

90

4

90

90% Sens/Spec

0.46

0.52

108

11

107

12

28

p-Tau 217 (pg mL−1)

95% Sens/Spec

0.12

0.29

81

6

99

5

75

95% NPV/PPV

0.10

0.29

63

3

99

5

96

90% Sens/Spec

0.16

0.22

101

12

110

13

30

  1. Model A (Plasma p-Tau217).
  2. Model B (Plasma p-Tau217 + ApoE + age).
  3. Sens Sensitivity, Spec Specificity, NPV Negative predictive value, PPV Positive predictive value.
  4. TN true negative, FN false negative, TP true positive, FP false positive.
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