Fig. 3 | Scientific Reports

Fig. 3

From: STAU1 exhibits oncogenic characteristics and modulates alternative splicing and gene expression in lung adenocarcinoma cells

Fig. 3

Stau1 regulates gene expression in human A549 cells. (A) PCA based on the FPKM values of all the detected Stau1 knockdown genes. The ellipse for each group is the confidence ellipse. (B) Volcano plot showing all differentially expressed genes (DEGs) between Stau1 knockdown (siStau1) and NC samples. (C) Hierarchical clustering heatmap displaying the expression of DEGs. (D) Scatter plot showing the most enriched GO pathway results of the upregulated DEGs. (E) The GSEA enrichment analysis results revealed the hallmark epithelial mesenchymal transition pathways. (F) Bar plot showing the expression patterns and significant differences in DEGs among several important genes. The error bars represent the means ± SEMs. ***P value < 0.001. The histogram shows the RT‒qPCR results for the Stau1-knockdown (siStau1) and NC samples. The error bars represent the means ± SEMs. **** P value < 0.0001.

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