Fig. 4
Oxidative phosphorylation inhibition reduced cortical area and moment of inertia. (A) Evaluation of bioenergetic inhibition on load-induced bone formation: Four days prior to the initiation of tibial loading, glycolysis and oxidative phosphorylation were inhibited via sodium oxamate and MSDC-containing chow, respectively. Sodium oxamate and MSDC administration continued throughout loading. n = 7–10/group (B, C) Cortical area was increased with loading and decreased with oxidative phosphorylation inhibition. (D, E) Cortical maximum moment of inertia was increased with loading and reduced with oxidative phosphorylation inhibition. Letters indicate loading or loading*age interaction effects. # indicates treatment effects. * indicates age effects.
