Table 2 Prevalence of antimalarial resistance markers during 2021 and 2022 rainy seasons in Mozambique.
2021 | All regions | South | Centre | North | p-value |
|---|---|---|---|---|---|
pfk13 | |||||
Validated mutants | 0/311 (0%) | 0/72 (0%) | 0/108 (0%) | 0/131 (0%) | - |
Any nsyn mutants* | 6/297 (2%) | 0 (0%) | 2/102 (2%) | 4/125 (3.2%) | 0.439 |
pfdhfr | |||||
N51I | 312/312 (100%) | 72/72 (100%) | 107/107 (100%) | 133/133 (100%) | - |
C59R | 311/312 (99.7%) | 72/72 (100%) | 106/107 (99.1%) | 133/133 (100%) | 0.383 |
S108N | 313/313 (100%) | 72/72 (100%) | 107/107 (100%) | 134/134 (100%) | - |
triple 51-59-108 | 238/239 (99.6%) | 70/70 (100%) | 75/76 (98.7%) | 93/93 (100%) | 0.341 |
pfdhps | |||||
S436A/C/F/H | 41/313 (13.1%) | 1/71 (1.4%) | 8/106 (7.6%) | 32/135 (23.7%) | < 0.001 |
A437G | 298/312 (95.5%) | 69/71 (97.2%) | 101/106 (95.3%) | 128/135 (94.8%) | 0.730 |
K540E | 296/313 (94.6%) | 70/72 (97.2%) | 101/107 (94.4%) | 125/134 (93.3%) | 0.491 |
A581G | 5/317 (1.6%) | 0/72 (0%) | 3/110 (2.7%) | 2/135 (1.5%) | 0.350 |
double 437–540 | 225/239 (94.1%) | 68/70 (97.14%) | 71/76 (93.4%) | 86/93 (92.5%) | 0.431 |
pfdhfr/pfdhps quintuple | 225/239 (94.1%) | 68/70 (97.1%) | 71/76 (93.4%) | 86/93 (92.5%) | 0.431 |
pfcrt 72–76 CVIET | 0/317 (0%) | 0/72 (0%) | 0/109 (0%) | 0/136 (0%) | - |
pfmdr1 Y184F | 216/313 (69%) | 37/71 (52.1%) | 76/107 (71%) | 103/135 (76.3%) | 0.001 |
2022 | All regions | South | Centre | North | p-value |
pfk13 | |||||
Validated mutants | 0/794 (0%) | 0/188 (0%) | 0/339 (0%) | 0/267 (0%) | - |
Any nsyn mutants* | 14/772 (1.8%) | 2/184 (1.1%) | 3/328 (0.9%) | 8/260 (3.1%) | 0.073 |
pfdhfr | |||||
N51I | 795/802 (99.1%) | 189/190 (99.5%) | 336/341 (98.5%) | 270/271 (99.6%) | 0.294 |
C59R | 796/802 (99.3%) | 190/190 (100%) | 335/341 (98.2%) | 271/271 (100%) | 0.017 |
S108N | 804/805 (99.9%) | 190/190 (100%) | 342/343 (99.7%) | 272/272 (100%) | 0.510 |
triple 51-59-108 | 645/658 (98.0%) | 181/182 (99.5%) | 259/270 (95.9%) | 205/206 (99.5%) | 0.005 |
pfdhps | |||||
S436A/C/F/H | 78/803 (9.7%) | 4/189 (2.1%) | 8/343 (2.3%) | 66/271 (24.4%) | < 0.001 |
A437G | 757/803 (94.3%) | 183/189 (96.8%) | 321/343 (93.6%) | 253/271 (93.4%) | 0.233 |
K540E | 751/801 (93.8%) | 181/189 (95.8%) | 319/341 (93.6%) | 251/271 (92.6%) | 0.381 |
A581G | 6/801 (0.8%) | 1/189 (0.5%) | 3/341 (0.9%) | 2/271 (0.7%) | 0.904 |
double 437–540 | 609/658 (92.6%) | 175/182 (96.2%) | 247/270 (91.5%) | 187/206 (90.8%) | 0.090 |
pfdhfr/pfdhps quintuple | 597/658 (90.7%) | 174/182 (96.6%) | 237/270 (87.8%) | 186/206 (90.3%) | 0.018 |
pfcrt 72–76 CVIET | 1/804 (0.1%) | 0/189 (0%) | 0/342 (0%) | 1/273 (0.4%) | 0.378 |
pfmdr1 Y184F | 565/803 (70.4%) | 114/190 (60%) | 242/343 (70.6%) | 209/270 (77.4%) | < 0.001 |
