Table 4 Demographic characteristics, parasitemia and genetic markers of drug resistance and diversity in Maputo and Manica provinces, by transmission season in 2022.
Maputo | Manica | |||||
|---|---|---|---|---|---|---|
Rainy | Dry | p-value | Rainy | Dry | p-value | |
N | 100 | 70 | 81 | 85 | - | |
Patient characteristics: | ||||||
Female, n (%) | 49 (49%) | 33 (47.1%) | 0.763 | 37 (45.7%) | 45 (52.9%) | 0.350 |
Age, median yr (IQR) | 15 (6, 28) | 8 (4, 29) | 0.118 | 6 (4, 8) | 5 (4, 7) | 0.738 |
Parasitemia, median parasites/µL (IQR) | 12,041 (1389, 42501) | 11,491 (1367, 33176) | 0.568 | 8648 (799, 37875) | 24,865 (1395, 61019) | 0.056 |
Drug resistance markers, n/N (%): | ||||||
pfk13 | ||||||
Validated mutants | 0/99 (0%) | 1/68 (1.5%) | 0.226 | 0/78 (0%) | 0/76 (0%) | - |
Any nsyn mutants* | 2/95 (2.1%) | 4/66 (6.1%) | 0.193 | 1/76 (1.3%) | 0/72 (0%) | 0.329 |
pfdhfr triple 51–59-108 | 94/94 (100%) | 62/62 (100%) | - | 56/59 (94.9%) | 60/64 (93.8%) | 0.780 |
pfdhps double 437–540 | 88/94 (93.6%) | 58/62 (93.6%) | 0.986 | 52/59 (88.1%) | 62/64 (96.9%) | 0.063 |
pfdhfr/pfdhps quintuple | 88/94 (93.6%) | 58/62 (93.5%) | 0.986 | 49/59 (83.1%) | 58/64 (90.6%) | 0.212 |
pfcrt 72–76 CVIET | 0/100 (0%) | 0/70 (0%) | - | 0/78 (0%) | 0/77 (0%) | - |
pfmdr1 Y184 F | 54/100 (54.0%) | 52/70 (74.3%) | 0.007 | 52/79 (65.8%) | 50/76 (65.8%) | 0.997 |
Diversity metrics: | ||||||
eCOI, median (IQR) | 1.1 (1, 1.9) | 1.5 (1, 2.2) | 0.161 | 1.8 (1, 2.2) | 1.7 (1, 2.4) | 0.614 |
% polyclonal, median (IQR) | 50% (40.4, 59.6) | 63.2% (51.4, 73.7) | 0.114 | 51.5% (50.4, 71.6) | 69.1% (57.4, 78.8) | 0.386 |
1-Fws, median (IQR) | 0.12 (0, 0.53) | 0.23 (0, 0.57) | 0.200 | 0.39 (0, 0.54) | 0.30 (0, 0.57) | 0.852 |
HE, median (IQR) | 0.58 (0.55, 0.61) | 0.58 (0.55, 0.60) | 0.295 | 0.58 (0.54, 0.61) | 0.56 (0.54, 0.59) | 0.017 |
