Fig. 3 | Scientific Reports

Fig. 3

From: Identification of non-charged 7.44 analogs interacting with the NHR2 domain of RUNX1-ETO with improved antiproliferative effect in RUNX-ETO positive cells

Fig. 3

Selectivity of hit compounds against RUNX1/ETO-dependent cells. (A) The efficacy of hit compounds M23, M27, and M10 identified in the initial screening, as well as the negative control M6, was further evaluated in the RUNX1/ETO-positive KASUMI cell line and compared against the RUNX1/ETO-negative K562 cell line. The mean ± STD of the IC50 values are depicted in µM, calculated by using a sigmoid dose-response curve and a nonlinear regression of the raw data normalized to the corresponding DMSO controls. Compounds with IC50 values over 1000 µM were classified as inactive (grey color). Data was collected from three independent experiments (n = 3). (B) Chemical structures of M23, M27, and M10.

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