Fig. 3
From: Dengue virus modulates critical cell cycle regulatory proteins in human megakaryocyte cells
Cell cycle regulatory proteins are mostly upregulated upon DENV2 infection. Heatmap (A) of all modulated proteins from DENV2-infected (top row) and uninfected (bottom row) microarray slides is shown in five colors. Heatmap was generated based on the normalization to the empty well from each block. The color intensity for each color pattern is based on the scale shown at left of the heatmap that indicates lower to higher expression. Positive marker and beta actin protein expression shows no significant difference between uninfected and DENV2-infected groups. Panel (B) shows all upregulated proteins and panel (C) shows all downregulated proteins upon DENV2 infection (collected from the microarray data). Bar graphs are created by normalizing each protein intensity to total intensity of actin. All upregulated and downregulated proteins were categorized based on their cell cycle phases (G1, S, G2, and M) and their specific relative activity during cell cycle progression. The asterisk shows significance, and *, ** or *** indicates, P value from non-paired two tail student’s t-test, shown as less than 0.05, 0.01, or 0.0001, respectively. Not significant values are denoted with ns.
