Fig. 4
From: Dengue virus modulates critical cell cycle regulatory proteins in human megakaryocyte cells
DENV2 upregulates several cells cycle regulatory gene transcripts in a time course kinetics. QRT-PCR analysis showing DENV2 capsid transcript levels (A), or CDK1 (B), CDK2 (C), CDK4 (D), CDK5 (E), CDK6 (F), CDK8, (G), Cyclin A1 (H), Cyclin B1 (I), Cyclin E (J), Cyclin G1 (K), Cyclin D3 (L), CDC2 (M) or CDC25A (N) gene expression at days 1, 3 and 5 post DENV2-infection. White bars represent uninfected group and black bars denotes DENV2-infected group. QRT-PCR data is shown as independent analysis for several cell cycle genes either present or absent in the microarray analysis. DENV2-loads and mRNA expression levels of cell cycle regulatory genes were normalized to human beta-actin mRNA levels. The asterisk shows significance, and *, or ** indicates, P value from non-paired two tail student’s t-test, shown as less than 0.05, or 0.01, respectively. Not significant values are denoted with ns.
