Fig. 4 | Scientific Reports

Fig. 4

From: Fungus-targeted nanomicelles enable microRNA delivery for suppression of virulence in Aspergillus fumigatus as a novel antifungal approach

Fig. 4

miRNA mimic-regulated conidia promoted decreased resistance to hydrogen peroxide and elimination by neutrophils. (A) Conidia harvested from each strain were treated with or without 1.1 mM H2O2 for 24 h, incubated on PDA, and CFUs were measured. The graph represents mean ± SEM. Statistical analysis: two-way ANOVA, ns = not significant, asterisk * or ** = p < 0.05 or p < 0.01, respectively. (B) CFUs were measured when each harvested conidia under each condition were co-incubated with or without neutrophils isolated from mice. The percentage decrease in CFU due to neutrophil co-culture is shown as the percent killing. The graph represents mean ± SEM. Statistical analysis: one-way ANOVA.

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