Table 1 Comparison between training cohort and validation cohort.

From: Personalized prediction model generated with machine learning for kidney function one year after living kidney donation

Variables

All

(N = 204)

Training cohort

(N = 143)

Validation cohort

(N = 61)

p

Age at donation (y.o)

59.9 ± 8.78

60.3 ± 8.70

59.0 ± 8.96

0.363

Male [n (%)]

71 (34.8)

53 (37.1)

18 (29.5%)

0.338

Body weight (kg)

56.0 (51.0, 63.9)

57.0 (51.0, 64.0)

53.0 (51.0, 61.0)

0.098

Hight (cm)

159.0(154.5, 165.0)

160 (155, 165)

159 (154, 164)

0.698

BMI

22.4 (20.4, 24.2)

22.6 (20.6,24.4)

21.9 (20.2, 23.2)

0.053

Systolic blood pressure (mmHg)

129.9 ± 19.9

130.7 ± 19.7

127.9 ± 20.3

0.357

Diastolic blood pressure (mmHg)

76.7 ± 14.3

77.4 ± 13.0

75.1 ± 17.0

0.284

smoking [n (%)]

58 (28.4)

42 (29.4)

16 (26.2)

0.736

History of CVD [n (%)]

4 (2.0)

3 (2.1)

1 (1.6)

1.000

Antihypertensive agents [n (%)]

40 (19.6)

27 (18.9)

13 (21.3)

0.703

Lipid-lowering agents [n (%)]

21 (10.3)

12 (8.4)

9 (14.8)

0.209

uric acid lowering agents [n (%)]

4 (2.0)

4 (2.8)

0 (0)

0.319

WBC (/µl)

4955 (4265, 6055)

4930 (4270, 5995)

5190 (4240, 6180)

0.490

Hb (g/dl)

13.7 ± 1.24

13.8 ± 1.27

13.6 ± 1.18

0.468

Platelet (*103/µl)

21.7 (18.2, 25.4)

22.0 (18.3, 25.3)

21.0 (18.2, 26.0)

0.846

Cre (mg/dl)

0.70 (0.62, 0.81)

0.69 (0.62, 0.84)

0.70 (0.62, 0.78)

0.612

eGFR (ml/min/1.73m2)

71.9 (65.1, 80.3)

71.4 (65.0, 80.2)

72.7 (65.1, 80.2)

0.650

BUN (mg/dl)

13.8 (11.2, 15.7)

13.8 (11.2, 15.8)

13.8 (11.7, 15.6)

0.646

Na (mEq/L)

142 (141,143)

142 (141, 143)

141 (141, 143)

0.417

K (mEq/l)

4.2 (4.0, 4.4)

4.2 (4.0, 4.4)

4.2 (4.0, 4.4)

0.917

AST [IU/l]

20.0 (17.0, 24.0)

20.0 (17.0, 24.5)

20.0 (17.0, 24.0)

0.849

ALT [IU/l]

17.0 (13.0, 22.0)

17.0 (13.0, 22.0)

17.0 (14.0, 23.0)

0.583

TP (g/dl)

7.24 ± 0.36

7.24 ± 0.37

7.24 ± 0.34

0.989

CRP (mg/dl)

0.05 (0.04, 0.10)

0.05 (0.04, 0.11)

0.05 (0.04, 0.10)

0.460

T.chol (mg/dl)

211 (187, 233)

213 (186, 233)

205 (190, 233)

0.521

UA (mg/dl)

4.80 (4.10, 5.90)

4.90 (4.10, 5.90)

4.70 (4.10, 5.90)

0.524

Glucose (g/dl)

98.0 (92.0, 104)

98.0 (92.0, 104)

98.0 (92.0, 107)

0.905

HbA1C (%)

5.70 (5.50, 5.90)

5.70 (5.50, 5.90)

5.70 (5.50, 5.90)

0.772

Proteinuria (+)

2 (1.0)

1 (0.7)

1 (1.6)

0.510

Urinary occult blood (≥+)

14 (6.9)

11 (7.7)

3 (4.9)

0.561

Cre at 1-year post-donation (mg/dl)

1.06 (0.93, 1.23)

1.06 (0.93, 1.26)

1.06 (0.91, 1.18)

0.378

Results of CT findings

 Volume of excised kidney (ml)

143 (126, 161)

148 (129, 163)

140 (118, 157)

0.133

 Volume of non-excised kidney(ml)

137 (120, 156)

138 (121, 159)

133 (114, 152)

0.165

 Area psoas muscle at L3(cm2)

11.3 (9.01,15.0)

11.5 (9.13, 14.9)

10.7 (8.92, 15.2)

0.501

 Area skeletal muscle at L3(cm2)

98.5 (85.8, 126)

100.5 (87.0, 126)

92.1 (82.5, 120)

0.139

 Area visceral fat(cm2)

86.4 (56.0, 125)

82.1 (58.2, 126)

90.2 (50.9, 115.7)

0.528

 Area visceral Fat at L3 (cm2)

77.2 (38.9, 127)

77.2 (46.1, 135)

81.1 (38.2, 118)

0.516

  1. Continuous data are presented as mean ± SD or median (IQR): CVD, cardiovascular disease; WBC, white blood cell; Hb, hemoglobin; Cre, creatinine; eGFR, estimated glomerular filtration rate; BUN, blood urea nitrogen; Na, sodium; K, potassium; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TP, total protein; CRP, C-reactive protein; T.chol, total cholesterol; UA, uric acid; HbA1C, hemoglobinA1C.
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