Fig. 5 | Scientific Reports

Fig. 5

From: Decoding the relationship between oxidative stress and antiseizure medications using network pharmacology and molecular docking

Fig. 5

The involvement of the identified hub proteins from CBZ targets— (A) EGFR, (B) GSK3B, and (C) STAT3 with epilepsy/oxidative stress. Since the identified hub proteins have been shown to be involved with oxidative stress/epilepsy through various mechanisms, we are presented with a variety of potential therapeutic targets. The hub proteins together with any other components of related pathways can be exploited therapeutically. †CBZ-Carbamazepine; EGFR-Epidermal Growth Factor Receptor; GSH-Reduced glutathione; GPx-Glutathione peroxidase; xCT-Cysteine/glutamate transporter; PI3K-Phosphoinositide-3 kinase; GSK3B-Glycogen Synthase 3 Kinase beta; STAT3-Signal Transducer and Activator of Transcription 3 (Figure created using MS PowerPoint Version 2501).

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