Table 1 CAII, CAIX and CAXII Inhibition values of newly synthesized hybrid compounds 8a–j.

From: Synthesis and evaluation of thiazolyl coumarin drug conjugates as carbonic anhydrase isozyme inhibitors by using integrated invitro and insilico approaches

Codes

CAII

CAIX

CAXII

IC50 ± SEM (µM)

8a

5.16 ± 0.61

2.77 ± 0.13

–

8b

1.54 ± 0.08

0.32 ± 0.04

–

8c

–

1.69 ± 0.11

0.79 ± 0.01

8d

0.38 ± 0.02

5.74 ± 0.35

0.61 ± 0.05

8e

0.68 ± 0.02

1.91 ± 0.11

–

8f

1.29 ± 0.25

4.38 ± 0.43

–

8g

4.12 ± 0.17

1.35 ± 0.15

2.82 ± 0.15

8h

5.86 ± 0.68

0.86 ± 0.02

6.18 ± 0.98

8i

2.01 ± 0.13

–

3.87 ± 0.65

8j

4.61 ± 0.67

0.11 ± 0.03

1.88 ± 0.11

Acetazolamidea

1.19 ± 0.04a

1.08 ± 0.03 a

1.55 ± 0.04 a

  1. aAcetazolamide (reference).
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