Fig. 4
From: Serum metabolic profiling in rheumatic heart disease and degenerative aortic stenosis
Correlation analysis of the cardiac remodelling parameters and valve calcification with metabolites detected in RHD patients and degenerative AS patients after adjustment for sex, age, race, BMI, hypertension, diabetes, and batch effects. Correlation of LVEF in RHD patients with (a) differences in the levels of 7-HOCA and deoxycholate, (b) the ratio of 7-HOCA to deoxycholate, and (c) butyrylcarnitine. (d) The correlation of the LVMI in RHD patients with the propionylcarnitine and acetoacetate ratio. (e) The correlation of the left atrial area with acetoacetate and the propionylcarnitine ratio in patients with degenerative aortic stenosis. (f) Levels of cortisol in valvular heart disease patients (RHD and AS) with and without valve calcifications on histology. (For all the plots, RHD n = 33, AS samples n = 9; *p value < 0.05; adj. rs = adjusted Spearman’s rank correlation coefficient). (RHD rheumatic heart disease, AS aortic stenosis, LVEF left ventricular ejection fraction, LVMI left ventricular mass index, LA left atrium, 7-HOCA 7α-Hydroxy-3-oxo-4-cholestenoic acid).
