Table 2 Summary of perturbed metabolites in rheumatic heart disease (RHD) patients, aortic stenosis (AS) patients, and controls.
From: Serum metabolic profiling in rheumatic heart disease and degenerative aortic stenosis
Metabolite putative annotation | RT | m/z | HMDB ID | MSI confidence level | CV(QC) | f.value | ANOVA raw p.value | FDR adjusted p value | Post hoc (Tukey’s HSD p < 0.05) |
|---|---|---|---|---|---|---|---|---|---|
Tryptophan | 11.425 | 205.0962 | HMDB0000929 | 2 | 0 | 11.656 | 0.0000638 | 0.0042878 | Controls-AS; RHD-AS |
Phenylacetylglutamine | 13.722 | 265.1174 | HMDB0006344 | 2 | 20 | 11.082 | 0.0000953 | 0.0042878 | Controls-AS; RHD-AS |
Indole-3-acetic acid | 20.958 | 130.0642 | HMDB0302181 | 2 | 30 | 7.9941 | 0.00092423 | 0.015695 | Controls-AS; RHD-AS |
Deoxycholate | 40.586 | 357.2784 | HMDB0000626 | 2 | 26 | 7.6633 | 0.0011931 | 0.015695 | Controls-AS; RHD-AS |
Carnitine | 2.055 | 161.5846 | HMDB0000062 | 2 | 19 | 7.125 | 0.0018175 | 0.020446 | Controls-AS; RHD-AS |
Cortisol | 26.117 | 363.2144 | HMDB0000063 | 2 | 30 | 6.8874 | 0.0021933 | 0.021719 | Controls-AS; RHD-AS |
Keto-hydroxypimelic acid | 2.318 | 191.0545 | C05601 | 3 | 19 | 6.7672 | 0.0024132 | 0.021719 | Controls-AS; RHD-AS |
3-Formylindole | 19.936 | 146.0596 | HMDB0029737 | 2 | 0 | 6.266 | 0.0036081 | 0.029521 | RHD-Controls |
PA(8:0/13:0) | 34.586 | 512.3346 | HMDB0115484 | 3 | 17 | 5.5851 | 0.0062948 | 0.038042 | Controls-AS; RHD-AS |
But-2-enoic acid | 1.849 | 85.02982 | HMDB0010720 | 3 | 19 | 5.557 | 0.0064425 | 0.038042 | Controls-AS; RHD-Controls |
Taurine | 1.784 | 181.9649 | HMDB0000251 | 2 | 19 | 5.4956 | 0.0067781 | 0.038042 | Controls-AS; RHD-Controls |
Propionylcarnitine | 6.234 | 218.1391 | HMDB0000824 | 2 | 0 | 5.3564 | 0.0076084 | 0.038042 | Controls-AS; RHD-AS |
10-Nitroelaidic acid | 30.709 | 328.2467 | HMDB0062737 | 3 | 17 | 5.1739 | 0.0088597 | 0.039869 | Controls-AS; RHD-AS |
Butyrylcarnitine | 9.61 | 232.1534 | HMDB0002013 | 2 | 16 | 5.0704 | 0.0096628 | 0.041412 | Controls-AS; RHD-AS |
DG(a-15:0/i-12:0/0:0) | 47.195 | 521.4223 | HMDB0093443 | 3 | 16 | 4.8586 | 0.01155 | 0.047249 | Controls-AS; RHD-AS |
LysoPC(18:1/0:0) | 42.11 | 566.3257 | HMDB0002815 | 2 | 16 | 4.7901 | 0.012239 | 0.047891 | RHD-Controls |
Oxo-pentenoic acid | 1.835 | 97.02824 | LMFA01060166 | 3 | 23 | 4.3988 | 0.017083 | 0.061928 | RHD-Controls |
Dehydromaticaria ester | 1.651 | 190.9122 | HMDB0033765 | 3 | 17 | 4.3907 | 0.017202 | 0.061928 | RHD-AS |
Tetradecanoylcarnitine | 37.369 | 394.295 | HMDB0005066 | 3 | 30 | 3.9764 | 0.024601 | 0.076349 | RHD-Controls |
Decatriynoic acid | 1.806 | 97.02925 | LMFA01050235 | 3 | 30 | 3.7492 | 0.029999 | 0.088272 | RHD-Controls |
Cyclo(L-prolyl-L-valyl) | 12.842 | 197.1278 | HMDB0240493 | 2 | 16 | 3.7338 | 0.030405 | 0.088272 | RHD-Controls |
LysoPE(0:0/22:5) | 42.435 | 528.3096 | HMDB0011494 | 3 | 26 | 3.6515 | 0.032682 | 0.091919 | RHD-Controls |
2-Amino-4-hydroxy-3-methylpentanoate | 1.977 | 146.0822 | HMDB0029449 | 3 | 4 | 3.253 | 0.046498 | 0.10128 | Controls-AS; RHD-AS |
Desmeninol | 2.437 | 133.032 | HMDB0037115 | 3 | 26 | 3.2431 | 0.04691 | 0.10128 | Controls-AS; RHD-AS |
LysoPC(16:1) | 41.786 | 494.3221 | HMDB0010383 | 2 | 16 | 3.2407 | 0.047012 | 0.10128 | RHD-Controls |
Ursodeoxycholic acid | 40.191 | 357.2795 | HMDB0000946 | 2 | 26 | 3.2327 | 0.047349 | 0.10128 | RHD-Controls |
