Table 3 Cox proportional hazards regression analysis of immune cell infiltration, tumor stage, and prognostic biomarkers in LIHC and STAD.

From: LZTS2 methylation as a potential diagnostic and prognostic marker in LIHC and STAD: Evidence from bioinformatics and in vitro analyses

Cancer type

Immune cell type

Variable name

Coef

Hazard ratio (HR)

Standard error

Lower limit of 95% confidence interval (95%CI_l)

Upper limit of 95% confidence interval (95%CI_u)

z value

p value

Signif

LIHC

T cell CD8 + 

CD8 + 

−2.748

0.064

1.112

0.007

0.566

−2.471

0.013

*

Stage2

0.282

1.326

0.252

0.809

2.172

1.12

0.263

 

Stage3

0.996

2.706

0.216

1.772

4.134

4.606

0

***

Stage4

1.729

5.633

0.603

1.728

18.361

2.868

0.004

**

LZTS2

0.226

1.254

0.096

1.039

1.514

2.354

0.019

*

STAD

T cell CD8 + 

CD8 + 

−0.3

0.741

1.085

0.088

6.216

−0.276

0.782

 

Stage2

0.392

1.48

0.334

0.769

2.847

1.175

0.24

 

Stage3

0.852

2.344

0.312

1.272

4.318

2.731

0.006

**

Stage4

1.312

3.712

0.357

1.845

7.467

3.678

0

***

LZTS2

0.017

1.017

0.113

0.815

1.27

0.153

0.878

 

LIHC

T cell CD4 + 

CD4 + 

4.834

125.748

1.274

10.346

1528.317

3.794

0

***

Stage2

0.187

1.206

0.256

0.73

1.992

0.732

0.464

 

Stage3

0.91

2.484

0.218

1.621

3.806

4.179

0

***

Stage4

1.651

5.214

0.602

1.601

16.98

2.741

0.006

**

LZTS2

0.172

1.187

0.101

0.974

1.448

1.696

0.09

·

STAD

T cell CD4 + 

CD4 + 

−0.926

0.396

0.915

0.066

2.378

−1.013

0.311

 

Stage2

0.401

1.494

0.334

0.776

2.873

1.202

0.23

 

Stage3

0.868

2.383

0.312

1.292

4.394

2.78

0.005

**

Stage4

1.344

3.833

0.358

1.9

7.73

3.754

0

***

LZTS2

−0.012

0.988

0.115

0.788

1.239

−0.102

0.919

 

LIHC

B Cell

B cell plasma

0.788

2.198

1.95

0.048

100.466

0.404

0.686

 

Stage2

0.286

1.332

0.254

0.81

2.189

1.129

0.259

 

Stage3

0.982

2.67

0.217

1.746

4.083

4.531

0

***

Stage4

1.601

4.96

0.602

1.525

16.137

2.661

0.008

**

LZTS2

0.224

1.252

0.097

1.034

1.515

2.305

0.021

*

STAD

B Cell

B cell plasma

2.003

7.413

1.483

0.405

135.551

1.351

0.177

 

Stage2

0.389

1.476

0.333

0.768

2.838

1.168

0.243

 

Stage3

0.834

2.303

0.312

1.249

4.244

2.674

0.007

**

Stage4

1.25

3.491

0.36

1.724

7.069

3.473

0.001

**

LZTS2

0.02

1.02

0.113

0.818

1.273

0.179

0.858

 

LIHC

Neutrophil

Neutrophil

−0.528

0.59

4.765

0

6703.706

−0.111

0.912

 

Stage2

0.297

1.346

0.252

0.821

2.206

1.179

0.238

 

Stage3

0.993

2.701

0.219

1.76

4.144

4.547

0

***

Stage4

1.613

5.018

0.602

1.543

16.319

2.681

0.007

**

LZTS2

0.219

1.245

0.096

1.031

1.504

2.275

0.023

*

STAD

Neutrophil

Neutrophil

7.104

1217.297

3.382

1.608

921,619.939

2.1

0.036

*

Stage2

0.408

1.504

0.333

0.782

2.89

1.223

0.221

 

Stage3

0.873

2.394

0.312

1.3

4.41

2.802

0.005

**

Stage4

1.345

3.836

0.357

1.906

7.723

3.766

0

***

LZTS2

0.061

1.063

0.115

0.848

1.331

0.528

0.598

 

LIHC

Macrophage

Macrophage

1.637

5.137

0.709

1.28

20.615

2.309

0.021

*

Stage2

0.282

1.326

0.253

0.808

2.175

1.116

0.264

 

Stage3

0.958

2.605

0.217

1.702

3.989

4.406

0

***

Stage4

1.727

5.621

0.604

1.72

18.373

2.857

0.004

**

LZTS2

0.144

1.155

0.104

0.942

1.417

1.383

0.167

 

STAD

Macrophage

Macrophage

1.717

5.568

0.518

2.017

15.365

3.315

0.001

**

Stage2

0.413

1.511

0.334

0.785

2.907

1.235

0.217

 

Stage3

0.828

2.289

0.312

1.243

4.218

2.657

0.008

**

Stage4

1.312

3.715

0.357

1.846

7.476

3.677

0

***

LZTS2

−0.078

0.925

0.117

0.735

1.165

−0.661

0.509

 

LIHC

Myeloid dendritic cell resting

Myeloid dendritic cell resting

7.312

1498.459

3.632

1.213

1,850,671.877

2.013

0.044

*

Stage2

0.296

1.344

0.252

0.821

2.201

1.175

0.24

 

Stage3

1.01

2.746

0.216

1.798

4.195

4.673

0

***

Stage4

1.628

5.093

0.602

1.566

16.561

2.706

0.007

**

LZTS2

0.206

1.229

0.098

1.015

1.489

2.109

0.035

*

STAD

Myeloid dendritic cell activated

Myeloid dendritic cell activated

−3.429

0.032

0.664

0.009

0.119

−5.164

0

***

Stage2

0.176

1.192

0.222

0.772

1.84

0.792

0.428

 

Stage3

0.61

1.84

0.204

1.233

2.747

2.983

0.003

**

Stage4

1.255

3.508

0.399

1.604

7.672

3.143

0.002

**

LZTS2

−0.047

0.955

0.136

0.731

1.247

−0.341

0.733