Fig. 1 | Scientific Reports

Fig. 1

From: Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation

Fig. 1

A representative composite image from nine eRA synovial samples generated after MIHC showing the presence of all five human FHR proteins along with complement component C3c and membrane attack complex (a.k.a. C5b-9). A The presence of FHR1 (magenta color), FHR2 (white color), FHR3 (green color), FHR4 (pink color), FHR5 (yellow color), FH (cyan color), C3c (red color) and MAC (C5b-9) (orange color) has been shown in the synovial biopsies. B FHR2 and FHR3 compared with FH dominantly present in the synovial lining of synovial biopsies. A false color-coding key was used for each complement protein shown in this composite image. Adipocytes = black cobble-like stone cells in the synovium. A minimum of three to five composite images were generated using a single synovial biopsy with 2 sections from each patient. eRA synovial biopsies n = 9. Magnification = × 40. Scale bar = 100 μm. *p < 0.05.

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