Fig. 2 | Scientific Reports

Fig. 2

From: Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation

Fig. 2

Showing percentage of FHR, FH, C3c and MAC single and double positive synovial cells in the synovium from eRA patients. MIHC was used to generate composite images followed by quantitation of single and double positive cells showing the presence of FHR1, FHR2, FHR3, FHR4, FHR5, FH, C3c, and MAC. A Presence of single positive synovial cells expressing FHR1, FHR2, FHR3, FHR4, FHR5, FH, C3c, and MAC. B Presence of double positive synovial cells positively stained for proteins FHR1/C3c, FHR2/C3, FHR3/C3, FHR4/C4, FHR5/C3c, FH/C3c and MAC/C3c. Synovial cells expressed a lower level of FHR1, FHR4, FHR5 and MAC. eRA synovial biopsies n = 8. Data are shown as mean ± SEM. *p < 0.05 considered significant.

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