Fig. 3 | Scientific Reports

Fig. 3

From: Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation

Fig. 3

A representative composite image from eight synovial samples showing the presence of macrophages and fibroblasts expressing FHR proteins in eRA patients. A Synovial cells showing the presence of FHR1 (magenta color), FHR2 (white color), FHR3 (green color), FHR4 (pink color), FHR5 (yellow color), FH (cyan color), DAPI (blue), macrophages (red color) and fibroblasts (orange color). B Synovium cells showing the predominance of FHR3 (green color) in the sub synovial lining area. A false color-coding key was used for each complement protein, macrophages and fibroblasts shown in this composite image. Adipocytes = black cobble-like stone cells in synovium. A minimum of three to five composite images were generated using a single synovial biopsy with 2 sections from each patient. Magnification = × 40. eRA synovial biopsies n = 8. Scale bar = 100 μm.

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