Fig. 4 | Scientific Reports

Fig. 4

From: Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation

Fig. 4

Bar graphs show the presence of macrophages and fibroblasts positive for individual FHR proteins in the synovium from eRA patients. MIHC composite images were analyzed for the presence of percentages of synovial macrophages (CD68 positive) and fibroblasts (FAP) positive for FHR1, FHR2, FHR3, FHR4 and FHR5 proteins. A Percentage of macrophages positive for FHR1, FHR2, FHR3, FHR4 and FHR5 proteins. B Percentage of fibroblasts positive for FHR1, FHR2, FHR3, FHR4 and FHR5 proteins. Both macrophages and fibroblasts have a low level of FHR1, FHR4 and FHR5 proteins compared with FHR2 and FHR3 proteins. eRA synovial biopsies n = 8. Data are shown as mean ± SEM. *p < 0.05 considered significant.

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