Fig. 5 | Scientific Reports

Fig. 5

From: Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation

Fig. 5

Representative snapshots of MIHC composite images showing the regional and differential distribution of FHR proteins in the synovial biopsies from eRA patients. A Composite image showing coexistence of FHR2/FH in the synovial lining but coexistent of FHR5/FH in the sub synovial lining area. B FH is predominately present in the sub synovial lining area, not in the synovial lining area. C FHR1 and FHR4 proteins are positively stained in cells in the synovial lining area. FHR3 is also present in the sub-synovial lining areas. D C3c is predominately and constantly present in the synovial lining cells. The coexistence of FHR1, FHR2, and FHR4 was also noticed in the sub-synovial lining areas. A false color-coding key represents FHR1 = magenta, FHR2 = white, FHR3 = green, FHR4 = pink, FHR5 = yellow, C3c = red, FH = cyan and DAPI = blue. SL = synovial lining. SSL = sub synovial lining Magnification = × 40. eRA synovial biopsies n = 4. Scale bar = 100 μm.

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