Table 3 Adjusted odds ratio of implantation failure according to paternal age respectively: AMCHS, China.

From: Effects of paternal age and interaction with smoking, alcohol consumption and maternal age on implantation failure in women undergoing ART

Paternal age

Model 1

Model 2

Model 3

Model 4

(year)

OR1

95% CI

P

OR2

95% CI

P

OR3

95% CI

P

OR4

95% CI

P

22-<35†

1.00

  

1.00

  

1.00

  

1.00

  

35-<40

1.53

1.19–1.96

< 0.001

1.50

1.16–1.93

0.002

1.18

0.89–1.57

0.263

1.19

0.89–1.60

0.237

40-<45

2.04

1.34–3.11

< 0.001

2.06

1.34–3.16

< 0.001

1.32

0.81–2.16

0.272

1.31

0.79–2.16

0.296

45–57

4.00

2.17–7.38

< 0.001

3.80

2.50–7.07

< 0.001

2.24

1.13–4.6

0.021

2.13

1.06–4.29

0.034

  1. † due to no significant differences in odds of implantation failure among the groups of 22-<25, 25-<30 and 30-<35, the three groups were combined as one group as a reference group for analysis, increasing the statistical power in multiple adjusted regression analysis.
  2. 1 Model 1: adjusted for adjusted for urban-rurality, annual family income, male smoking and alcohol drinking,
  3. 2 Model 2: adjusted for factors in model 1, plus male depression (score), male anxiety, histories of any serious illness in men, semen volume, and semen morphology,
  4. 3 Model 3: adjusted for factors in model 2, plus female age (cont.),
  5. 4 Model 4: adjusted for factors in model 3, plus female occupation, female drinking alcohol, female BMI, female depression, female anxiety, infertility type, infertility duration, anovulation, and antral follicle count.
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