Fig. 5 | Scientific Reports

Fig. 5

From: Characteristic gene expression profile of intestinal mucosa early in life promotes bacterial colonization leading to healthy development of the intestinal environment

Fig. 5

Ileal mucosal gene expression in germ-free mice early vs. later in life. (A) Principal component analysis plots of ileal mucosal gene expression profiles in germ-free (GF) mice at 4 weeks of age [early life (EL) group] and 10 weeks of age [later life (LL) group]. Red and blue dots represent EL and LL groups, respectively (n = 10 per group, black filled circle: female, black filled diamond: male). (B) Volcano plots of gene expression in the ileal mucosa of EL vs. LL groups. Red and blue dots indicate a gene that was expressed predominantly in EL or LL group, respectively (expression ratio > twofold and p < 0.05 between the two groups). A gray dot represents a gene that did not satisfy the criterion. (C) Characteristics annotated by enrichment analysis of genes predominantly expressed in the ileal mucosa in the EL group. (D) Characteristics annotated by enrichment analysis of genes predominantly expressed in the ileal mucosa in the LL group. Colon data are shown in Fig. S10.

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