Fig. 6 | Scientific Reports

Fig. 6

From: Characteristic gene expression profile of intestinal mucosa early in life promotes bacterial colonization leading to healthy development of the intestinal environment

Fig. 6

Correlations between ileal gene expression and bacterial genera that colonized mice early in life. (A) Correlation analysis of gene expression in the ileal mucosa and bacterial amplicon sequencing variants (ASVs). In the heat map, each row represents a bacterial ASV derived from adult donors (1387 ASVs) and each column represents a gene that was expressed predominantly in the EL group (66 genes, red line) or LL group (54 genes, blue line). (B) Relative abundance of the genus Lachnospiraceae NK4A136 group in specific pathogen-free (SPF) mice at 4 vs. 10 weeks of age. (C) Relative abundance of the genus Roseburia in SPF mice at 4 vs. 10 weeks of age. (D) Total relative abundance of genera Lachnospiraceae NK4A136 group and Roseburia in SPF mice at 4 vs. 10 weeks of age. Data are described as the mean ± SEM (n = 10, black filled circle: female, black filled diamond: male). *p < 0.05, **p < 0.01. Colon data are shown in Fig. S11.

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