Table 5 The secondary KRAS mutation rate stratified by the duration of anti-EGFR therapy in the chemotherapy plus cetuximab subgroups of Group B and Group C.

From: Retrospective stratified analysis of resistance mechanisms to anti-EGFR therapy in mCRC using tumor tissue samples

Group

Wild type

Mutation type

Total

Rate

The subgroup with an anti-EGFR therapy duration of less than 10 months

16

1

17

5.9% (1/17)

The subgroup with an anti-EGFR therapy duration of more than 10 months

6

2

8

25.0% (2/8)

Total

22

3

25

12.0% (3/25)

  1. Group B, first-line chemotherapy without progression group; Group C, first-line chemotherapy with progression group.