Table 1 The cytotoxic activity, antiviral activity, and selectivity indices of Compound 24.

From: Sulfonohydrazide as a potential inhibitor of SARS-CoV-2 infection

S#

Compound/ IUPAC

CC50 (µM)

IC50 (µM)

SI (CC50/ IC50)

1

Compound 24

202.3

8.320

24.31

2

Remdesivir

307.2

31.54

9.7

  1. SI (Selectivity Index) = (CC50 Vero cell line/IC50 SARS-CoV-2 infected cell line). * Experiments were done in triplicate and repeated at least three times. The CC50 and IC50 values were calculated using nonlinear regression analysis of GraphPad Prism software (version 8) by plotting log inhibitor versus normalized response (variable slope).
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